Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 8/20 | 0.62 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838360 | 0.92 | HDAC4 (0.52) | HDAC4AKR1C1HDAC1SMN1; SMN2HTT | |
| SCHEMBL31564890 | 0.79 | HDAC4 (0.47) | HDAC4AKR1C1HDAC1SMN1; SMN2HTT | |
| SCHEMBL724772 | 0.79 | HDAC1 (0.46) | HDAC4AKR1C1HDAC1SMN1; SMN2LMNA | |
| SCHEMBL4748287 | 0.78 | HDAC4 (0.60) | HDAC4HDAC1LMNAALDH1A1 | |
| SCHEMBL13485795 | 0.77 | HDAC4 (1.00) | HDAC4AKR1C1HDAC1SMN1; SMN2HTT | |
| SCHEMBL3663470 | 0.76 | AKR1C1 (0.59) | HDAC4AKR1C1SMN1; SMN2HTTLMNA | |
| SCHEMBL16132896 | 0.76 | HDAC4 (1.00) | HDAC4AKR1C1HDAC1SMN1; SMN2HTT | |
| SCHEMBL17502816 | 0.76 | HDAC4 (1.00) | HDAC4AKR1C1HDAC1SMN1; SMN2HTT | |
| SCHEMBL23588276 | 0.74 | HDAC1 (0.41) | HDAC4HDAC1HDAC9ALDH1A1 | |
| SCHEMBL12235292 | 0.74 | AKR1C1 (0.55) | HDAC4AKR1C1SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272848-B1 | Xanthine derivatives as selective HM74A agonists | GLAXOSMITHKLINE LLC (US) | 2012-12-26 | — | — | EP | disclosed |
| US-8143264-B2 | Xanthine derivatives as selective HM74A agonists | GLAXOSMITHKLINE LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110257205-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | GLAXOSMITHKLINE LLC | 2011-10-20 | — | — | US | disclosed |
| EP-2272848-A1 | Xanthine derivatives as selective HM74A agonists | Glaxosmithkline LLC (US) | 2011-01-12 | — | — | EP | disclosed |
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
| US-20100168122-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168122-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | GPR84, XDH, GPR88 | HDAC4 4425/4885AKR1C1 1232/4885HDAC1 4162/4885 |
| US-20110257205-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | GPR84, GPR88, XDH | HDAC4 4361/4885AKR1C1 1697/4885HDAC1 4403/4885 |
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | HDAC4 4423/4885AKR1C1 1317/4885HDAC1 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.