Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.52 |
| ▸ | BCR | P11274 | 5/20 | 0.52 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | PRKCA | P17252 | 4/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | PRKCH | P24723 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14374935 | 0.89 | BTK (0.49) | ABL1BCRSRCPRKCAPDGFRB | |
| SCHEMBL8349712 | 0.86 | ABL1 (0.53) | ABL1BCRSRCPRKCAPDGFRB | |
| SCHEMBL8352521 | 0.85 | ABL1 (0.58) | ABL1BCRSRCPRKCAPDGFRB | |
| SCHEMBL8352106 | 0.84 | SMN1; SMN2 (0.52) | PRKCAMAPK8LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8349425 | 0.82 | ABL1 (0.53) | ABL1BCRSRCPRKCAPDGFRB | |
| SCHEMBL8349452 | 0.80 | JAK2 (0.61) | ABL1BCRSRCPRKCAPDGFRB | |
| SCHEMBL4382510 | 0.80 | JAK2 (0.68) | ABL1BCRSRCEGFRCAMK2D | |
| SCHEMBL8351175 | 0.80 | HPGD (0.54) | ABL1BCRSRCPRKCAPDGFRB | |
| SCHEMBL14021170 | 0.78 | CAMK2D (0.57) | ABL1BCRPDGFRBPDGFRACAMK2D | |
| SCHEMBL5379812 | 0.78 | ABL1 (0.77) | ABL1BCRSRCPRKCAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |