Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.47 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | GRK2 | P25098 | 2/20 | 0.47 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350912 | 0.85 | CSNK1D (0.53) | MAPTMAPK8MAPK10JAK2ROCK1 | |
| SCHEMBL8351616 | 0.84 | ABL1 (0.52) | SMN1; SMN2LMNAMAPTMAPK8MAPK10 | |
| SCHEMBL8352104 | 0.84 | CFD (0.59) | SMN1; SMN2LMNAMAPK8MAPK10JAK2 | |
| SCHEMBL8349000 | 0.81 | MAPK10 (0.48) | LMNAMAPK8MAPK10JAK2ROCK2 | |
| SCHEMBL8351088 | 0.80 | ALDH1A1 (0.62) | SMN1; SMN2MAPTMAPK8MAPK10TP53 | |
| SCHEMBL8351021 | 0.79 | HPGD (0.56) | SMN1; SMN2LMNAMAPTMAPK8MAPK10 | |
| SCHEMBL1518585 | 0.78 | CNR1 (0.55) | SMN1; SMN2LMNAMAPTMAPK8MAPK10 | |
| SCHEMBL8352200 | 0.75 | MEN1 (0.60) | MAPK8MAPK10ROCK2PIP5K1CPIK3CA | |
| SCHEMBL14254327 | 0.74 | MAPK8 (0.59) | MAPTMAPK8MAPK10PIP5K1CPIK3CA | |
| SCHEMBL8351466 | 0.74 | ROCK2 (0.64) | LMNAMAPK8MAPK10ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |