Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358094 | 0.87 | SMN1; SMN2 (0.82) | SMN1; SMN2NPSR1POLBHSD17B10HTT | |
| SCHEMBL8351229 | 0.85 | GLS (0.58) | SMN1; SMN2POLBHSD17B10MAPTGAA | |
| SCHEMBL8353625 | 0.82 | GLS (0.63) | POLBHSD17B10GLSALDH1A1 | |
| SCHEMBL8356502 | 0.78 | HSD17B10 (0.47) | SMN1; SMN2POLBHSD17B10MAPTGAA | |
| SCHEMBL10769808 | 0.75 | HSD17B10 (0.64) | SMN1; SMN2NPSR1POLBHSD17B10HTT | |
| SCHEMBL5759573 | 0.75 | TP53 (0.71) | SMN1; SMN2POLBHSD17B10HTTMAPT | |
| SCHEMBL8356753 | 0.74 | TP53 (0.46) | SMN1; SMN2POLBHSD17B10MAPTGAA | |
| SCHEMBL8356519 | 0.73 | NPSR1 (0.54) | SMN1; SMN2NPSR1POLBHSD17B10MAPT | |
| SCHEMBL6877987 | 0.72 | GAA (0.59) | SMN1; SMN2POLBHTTGAAMEN1 | |
| SCHEMBL8358314 | 0.71 | HTT (1.00) | SMN1; SMN2NPSR1POLBHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |