Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GLS | O94925 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353189 | 0.78 | SMN1; SMN2 (0.61) | HSD17B10GLSALDH1A1MAPTHPGD | |
| SCHEMBL5759573 | 0.77 | TP53 (0.71) | HSD17B10ALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL8356753 | 0.77 | TP53 (0.46) | HSD17B10GLSALDH1A1MAPTTP53 | |
| SCHEMBL25144949 | 0.77 | ALDH1A1 (0.40) | HSD17B10ALDH1A1MAPTHPGDTP53 | |
| SCHEMBL8351229 | 0.75 | GLS (0.58) | HSD17B10GLSALDH1A1MAPTHPGD | |
| SCHEMBL8353625 | 0.73 | GLS (0.63) | HSD17B10GLSALDH1A1TP53CA12 | |
| SCHEMBL7367074 | 0.72 | CES1 (0.41) | HSD17B10GLSALDH1A1MAPTHPGD | |
| SCHEMBL8358094 | 0.71 | SMN1; SMN2 (0.82) | HSD17B10ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL18352875 | 0.70 | CES1 (0.42) | HSD17B10ALDH1A1MAPTHPGDTP53 | |
| SCHEMBL8350034 | 0.70 | POLB (0.68) | HSD17B10SMN1; SMN2GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |