SCHEMBL8353773

SCHEMBL8353773

O=P(O)(c1ccccc1)c1cccc(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.51
CA2 P00918 1/20 0.46
CA4 P22748 1/20 0.46
CA5A P35218 1/20 0.46
RAB9A P51151 4/20 0.43
NPC1 O15118 3/20 0.43
CFTR P13569 1/20 0.42
HTT P42858 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
MAPT P10636 2/20 0.42
LMNA P02545 2/20 0.42
KCNK3 O14649 1/20 0.41
KCNK9 Q9NPC2 1/20 0.41
TSHR P16473 5/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1069498 0.94 ACP3 (0.47) ACP3CA2CA4CA5ARAB9A
SCHEMBL916920 0.81 PGK1 (0.53) ACP3CA2CA4CA5AHTT
SCHEMBL31467547 0.81 PGK1 (0.53) ACP3CA2CA4CA5AHTT
SCHEMBL191567 0.80 CA2 (0.68) CA2CA4CA5ACFTRHTT
SCHEMBL11805101 0.79 PGK1 (0.52) ACP3CA2CA4CA5AHTT
SCHEMBL9098018 0.79 ACP3 (0.46) ACP3CA2CA4CA5ARAB9A
SCHEMBL19809603 0.78 CA2 (0.65) CA2CA4CA5ACFTRHTT
SCHEMBL19809596 0.78 CA2 (0.65) CA2CA4CA5ACFTRHTT
SCHEMBL19809604 0.78 CA2 (0.65) CA2CA4CA5ACFTRHTT
SCHEMBL190541 0.78 CA2 (0.65) CA2CA4CA5ACFTRHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5861107-A ESTER INTERCHANGE OF 1,3-PROPANEDIOL COMPOUNDS WITH CARBONIC ACID ESTERS; DISTILLATIVE DEPOLYMERIZATION; CATALYSIS WITH TITANIUM OR ZIRCONIUM COMPOUND; PHOSPHORUS OR SULFUR COMPOUND STABILIZER BAYER AKTIENGESELLSCHAFT (DE) 1999-01-19 US disclosed
EP-0816354-A1 Process for preparing and stabilisation of aliphatic six-membered cyclic carbonates BAYER AG (DE) 1998-01-07 EP disclosed