Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 11/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | PRKACG | P22612 | 1/20 | 0.40 |
| ▸ | PRKACB | P22694 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440435 | 0.90 | TOP1 (0.63) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL14440418 | 0.80 | TOP1 (0.63) | TOP1PRKCQROCK2PRKCAMAP3K5 | |
| SCHEMBL14440433 | 0.76 | TOP1 (0.46) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL14440442 | 0.76 | CDK4 (0.55) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL14440450 | 0.76 | TOP1 (0.56) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL8352252 | 0.76 | CDK4 (0.55) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL8354746 | 0.76 | CDK4 (0.55) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL8353620 | 0.76 | TOP1 (0.56) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL14440376 | 0.76 | TOP1 (0.56) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5666509 | 0.76 | TOP1 (0.69) | TOP1CDK4CCND1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| WO-2003051887-A1 | N-CARBACYCLE MONOSUBSTITUTED INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2003-06-26 | — | — | WO | disclosed |