Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 8/20 | 0.46 |
| ▸ | PRKCA | P17252 | 5/20 | 0.43 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440434 | 0.84 | TOP1 (0.44) | TOP1PRKCACDK4CCND1ROCK2 | |
| SCHEMBL14440432 | 0.80 | TOP1 (0.49) | TOP1PRKCACDK4CCND1ROCK2 | |
| SCHEMBL8354092 | 0.78 | PRKCA (0.50) | PRKCACDK4CCND1ROCK2MAP3K5 | |
| SCHEMBL14440435 | 0.77 | TOP1 (0.63) | TOP1CDK4CCND1ROCK2PRKCQ | |
| SCHEMBL8354446 | 0.76 | TOP1 (0.53) | TOP1PRKCACDK4CCND1ROCK2 | |
| SCHEMBL8354934 | 0.76 | ROCK2 (0.59) | PRKCACDK4CCND1ROCK2PRKCQ | |
| SCHEMBL8353621 | 0.72 | PRKCA (0.65) | PRKCACDK4CCND1ROCK2PRKCQ | |
| SCHEMBL8354004 | 0.72 | TOP1 (0.41) | TOP1CDK4CCND1ROCK2PRKCQ | |
| SCHEMBL14440336 | 0.71 | PRKCA (0.58) | PRKCACDK4CCND1ROCK2PRKCQ | |
| SCHEMBL14440414 | 0.69 | PRKCA (0.46) | PRKCACDK4CCND1ROCK2PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |