Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213150 | 0.83 | HPGD (0.57) | TP53CACNA1GCACNA1HHPGDLMNA | |
| Picolinic Acid Fluorobenzylamide SCHEMBL27812819 | 0.82 | TSHR (0.60) | TP53CACNA1GCACNA1HHPGDLMNA | |
| SCHEMBL20804370 | 0.79 | HPGD (0.67) | TP53HPGDLMNAMEN1KMT2A | |
| SCHEMBL8358830 | 0.76 | MMP13 (0.77) | MMP13CACNA1GCACNA1HMAOB | |
| SCHEMBL2914008 | 0.76 | HPGD (0.65) | HPGDLMNANPC1ALDH1A1MAPT | |
| SCHEMBL11118544 | 0.75 | TP53 (0.52) | TP53CACNA1GCACNA1HHPGDLMNA | |
| SCHEMBL8358839 | 0.75 | MMP13 (0.71) | MMP13TP53LMNAMEN1KMT2A | |
| SCHEMBL8358829 | 0.75 | MMP13 (0.70) | MMP13HPGDLMNAADORA3ADORA2A | |
| SCHEMBL7013158 | 0.74 | LMNA (0.53) | TP53CACNA1GCACNA1HHPGDLMNA | |
| SCHEMBL7013155 | 0.74 | LMNA (0.53) | TP53CACNA1GCACNA1HHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455790-B1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2003049738-A1 | USE OF PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND OF PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR SELECTIVE COLLAGENASE INHIBITION | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-06-19 | — | — | WO | disclosed |