SCHEMBL8355420

SCHEMBL8355420

O=S(=O)(NC1CCC(NS(=O)(=O)c2ccccc2)CC1)c1ccccc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.67
RECQL P46063 1/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
PARG Q86W56 1/20 0.59
CTSB P07858 3/20 0.57
CTSK P43235 3/20 0.57
UCHL1 P09936 2/20 0.57
CTSS P25774 2/20 0.57
CTSC P53634 2/20 0.57
USP30 Q70CQ3 2/20 0.57
CTSL P07711 1/20 0.57
PSEN1 P49768 1/20 0.56
PSEN2 P49810 1/20 0.56
APH1B Q8WW43 1/20 0.56
NCSTN Q92542 1/20 0.56
APH1A Q96BI3 1/20 0.56
PSENEN Q9NZ42 1/20 0.56
MMP2 P08253 1/20 0.56
MMP9 P14780 1/20 0.56
MMP13 P45452 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2225334 1.00 KDM4E (0.67) KDM4ERECQLSMN1; SMN2PARGCTSB
Hydrochloric Acid SCHEMBL15687975 0.98 KDM4E (0.64) KDM4ERECQLSMN1; SMN2PARGCTSB
SCHEMBL4041413 0.92 KDM4E (0.74) KDM4ERECQLSMN1; SMN2CTSBCTSK
SCHEMBL7648169 0.92 KDM4E (0.81) KDM4ERECQLSMN1; SMN2MMP2MMP9
SCHEMBL1722677 0.91 KDM4E (0.56) KDM4ERECQLSMN1; SMN2PARGCTSB
SCHEMBL9835393 0.91 KDM4E (0.56) KDM4ERECQLSMN1; SMN2PARGCTSB
SCHEMBL3066034 0.91 KDM4E (0.56) KDM4ERECQLSMN1; SMN2PARGCTSB
SCHEMBL11372059 0.91 LMNA (0.56) KDM4ERECQLSMN1; SMN2PARGCTSB
SCHEMBL12852936 0.91 KDM4E (0.56) KDM4ERECQLSMN1; SMN2PARGCTSB
SCHEMBL812698 0.90 SMN1; SMN2 (0.78) KDM4ERECQLSMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5264474-A Plasticizing thermoplastic or thermosetting resins with sulfonamide compounds MTM AMERICAS INC. (US) 1993-11-23 US claimed
US-5908898-A ELECTRICALLY INSULATIVE THERMOPLASTIC MATRIX POLYMER DISPERSED THROUGH AN INTRINSICALLY CONDUCTIVE POLYMER SALT THAT IS INCOMPATIBLE WITH THE MATRIX POLYMER, A THERMOPLASTIC CONDUCTIVE PHASE POLYMER THAT IS PARTIALLY COMPATIBLE WITH MONSANTO COMPANY (US) 1999-06-01 US disclosed
WO-1999019391-A1 INTRINSICALLY CONDUCTIVE POLYMER/PLASTICIZER BLENDS WITH ENHANCED CONDUCTIVITY ZIPPERLING KESSLER & CO. (GMBH & CO.) (DE) 1999-04-22 WO disclosed
US-5871671-A Intrinsically conductive polymer/plasticizer blends with enhanced conductivity MONSANTO COMPANY (US) 1999-02-16 US disclosed
US-5264474-A Plasticizing thermoplastic or thermosetting resins with sulfonamide compounds MTM AMERICAS INC. (US) 1993-11-23 US disclosed
US-4981890-A POLYHALOAROMATIC AND AROMATIC BIS-SULFONAMIDE ETHYL CORPORATION (US) 1991-01-01 US disclosed
US-4957958-A IMPROVED MELT FLOW ETHYL CORPORATION (US) 1990-09-18 US disclosed