Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL8355994

COC(=O)COS(=O)(=O)C(F)(F)F.S

nearest known ligand 0.36

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.36
CA12 O43570 3/20 0.35
CA14 Q9ULX7 3/20 0.35
F2 P00734 1/20 0.33
PRSS1 P07477 1/20 0.33
PRSS2 P07478 1/20 0.33
PRSS3 P35030 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
TET2 Q6N021 1/20 0.32
CA2 P00918 3/20 0.32
RECQL P46063 1/20 0.31
ALDH1A1 P00352 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
CA1 P00915 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1509202 0.98 TSHR (0.37) TSHRCA12CA14F2PRSS1
SCHEMBL8374416 0.81 CA2 (0.34) CA2ALDH1A1CA1
SCHEMBL9026191 0.78 TSHR (0.44) TSHRCA12CA14F2PRSS1
SCHEMBL27800814 0.78 PSEN1 (0.36) CA12CA14CA2CA1
SCHEMBL1730503 0.78 GAA (0.41) TSHRHSD17B10MGAMGAASI
SCHEMBL4953672 0.76 CA2 (0.36) TSHRCA2ALDH1A1CA1
SCHEMBL15858594 0.74 TSHR (0.42) TSHRCA12CA14HSD17B10MGAM
SCHEMBL3871542 0.74 CA2 (0.39) F2PRSS1PRSS2PRSS3CA2
SCHEMBL17777235 0.73 NAAA (0.42) TSHRPRSS1PRSS2PRSS3CA2
SCHEMBL28553919 0.72 TDP1 (0.35) CA2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11228534-A None JP disclosed
JP-H11228534-A NEW SULFONIUM SALT COMPOUND HAVING OXYCARBONYLMETHYL GROUP SANWA CHEMICAL:KK 1999-08-24 JP disclosed