SCHEMBL4953672

SCHEMBL4953672

O=C(O)COS(=O)(=O)C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.36
TSHR P16473 2/20 0.36
CTH P32929 1/20 0.36
CBS P35520 1/20 0.36
THPO P40225 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
THRB P10828 1/20 0.35
CA1 P00915 2/20 0.34
ALDH1A1 P00352 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
POLB P06746 1/20 0.32
CA9 Q16790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3871542 0.83 CA2 (0.39) CA2CA1ALDH1A1L3MBTL1CA9
SCHEMBL8374416 0.81 CA2 (0.34) CA2CA1ALDH1A1L3MBTL1
SCHEMBL17249650 0.79 CA2 (0.33) CA2CA1ALDH1A1L3MBTL1
SCHEMBL1509202 0.78 TSHR (0.37) CA2TSHRSMN1; SMN2CA1ALDH1A1
SCHEMBL5238163 0.76 CA2 (0.40) CA2TSHRCA1ALDH1A1L3MBTL1
SCHEMBL28553919 0.76 TDP1 (0.35) CA2CA1
Hydrogen Sulfide SCHEMBL8355994 0.76 TSHR (0.36) CA2TSHRCA1ALDH1A1
SCHEMBL5676976 0.75 CA2 (0.33) CA2CA1
SCHEMBL27800814 0.74 PSEN1 (0.36) CA2CA1
SCHEMBL1730503 0.74 GAA (0.41) TSHRSMN1; SMN2ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3752496-A1 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION GILEAD SCIENCES, INC. (US) 2020-12-23 EP claimed
WO-2019161280-A1 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION GILEAD SCIENCES, INC. (US) 2019-08-22 WO claimed
US-20240101533-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2024-03-28 US disclosed
EP-4253366-A2 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION Gilead Sciences, Inc. (US) 2023-10-04 EP disclosed
US-11760746-B2 Methods and intermediates for preparing therapeutic compounds GILEAD SCIENCES, INC. (US) 2023-09-19 US disclosed
EP-3752496-B1 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION GILEAD SCIENCES INC (US) 2023-07-05 EP disclosed
CN-114721222-A Polymer composition and method for manufacturing semiconductor device 台湾积体电路制造股份有限公司 2022-07-08 CN disclosed
US-20220009904-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2022-01-13 US disclosed
US-11117886-B2 Methods and intermediates for preparing therapeutic compounds GILEAD SCIENCES, INC. (US) 2021-09-14 US disclosed
EP-3752496-A1 METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION GILEAD SCIENCES, INC. (US) 2020-12-23 EP disclosed
US-20200369647-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2020-11-26 US disclosed
EP-0679652-A1 Process for preparing carbapenem compounds SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1995-11-02 EP disclosed
US-5457111-A Side effect reduction ABBOTT LABORATORIES (US) 1995-10-10 US disclosed
EP-0642516-A1 MACROCYCLIC IMMUNOMODULATORS ABBOTT LABORATORIES (US) 1995-03-15 EP disclosed
EP-0638082-A1 MACROCYCLIC IMMUNOMODULATORS ABBOTT LABORATORIES (US) 1995-02-15 EP disclosed
WO-1994021642-A1 MACROCYCLIC AMIDE AND UREA IMMUNOMODULATORS ABBOTT LABORATORIES (US) 1994-09-29 WO disclosed
EP-0642516-A4 MACROCYCLIC IMMUNOMODULATORS. ABBOTT LAB (US) 1994-06-15 EP disclosed
EP-0638082-A4 MACROCYCLIC IMMUNOMODULATORS. ABBOTT LAB (US) 1994-06-09 EP disclosed
WO-1993004680-A1 MACROCYCLIC IMMUNOMODULATORS ABBOTT LABORATORIES (US) 1993-03-18 WO disclosed
WO-1993004679-A1 MACROCYCLIC IMMUNOMODULATORS ABBOTT LABORATORIES (US) 1993-03-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220009904-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS CYP11A1, CYP11B1, CYP11B2 CA2 891/4885TSHR 3048/4885CTH 1962/4885
US-11117886-B2 Methods and intermediates for preparing therapeutic compounds CYP11A1, CYP11B1, CYP11B2 CA2 912/4885TSHR 3015/4885CTH 2045/4885
US-20240101533-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS CYP11A1, CYP11B1, CYP11B2 CA2 912/4885TSHR 3015/4885CTH 2045/4885
US-11760746-B2 Methods and intermediates for preparing therapeutic compounds CYP11A1, CYP11B1, CYP11B2 CA2 891/4885TSHR 3048/4885CTH 1962/4885
US-20200369647-A1 METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS CYP11A1, CYP11B1, CYP11B2 CA2 912/4885TSHR 3015/4885CTH 2045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.