Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358036 | 0.84 | POLB (0.72) | MAPK1MAPK10MAPTLMNATSHR | |
| SCHEMBL8351326 | 0.79 | MAPT (0.62) | MAPK1MAPK10MAPTLMNATSHR | |
| SCHEMBL8358322 | 0.78 | TSHR (0.71) | MAPK1MAPK10MAPTLMNATSHR | |
| SCHEMBL8354074 | 0.78 | MAPT (0.68) | MAPK1MAPK10MAPTLMNATSHR | |
| Hydrochloric Acid SCHEMBL8351225 | 0.78 | MAPT (0.67) | MAPK1MAPK10MAPTLMNATSHR | |
| SCHEMBL8351821 | 0.75 | MAPK10 (0.56) | MAPK1MAPK10MAPTLMNATSHR | |
| SCHEMBL31531433 | 0.75 | MAPK10 (0.69) | MAPK1MAPK10MAPTLMNATSHR | |
| SCHEMBL4001578 | 0.75 | DRD4 (0.69) | MAPK1MAPTLMNAHSD17B10GAA | |
| SCHEMBL4005288 | 0.74 | MAPK1 (0.70) | MAPK1MAPTLMNATSHRPOLB | |
| Hydrochloric Acid SCHEMBL1375801 | 0.73 | HSD11B1 (0.65) | MAPK1GAARBP4HSD11B1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |