Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358036 | 0.81 | POLB (0.72) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL31531433 | 0.80 | MAPK10 (0.69) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8350338 | 0.79 | MAPT (0.55) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8351821 | 0.79 | MAPK10 (0.56) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8356499 | 0.78 | MAPK1 (0.61) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8354074 | 0.78 | MAPT (0.68) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL8351225 | 0.77 | MAPT (0.67) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8350342 | 0.76 | MAPT (0.68) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8351326 | 0.75 | MAPT (0.62) | TSHRLMNAMAPTHSD17B10MAPK1 | |
| SCHEMBL8354036 | 0.74 | MAPK10 (0.51) | TSHRLMNAMAPTHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |