Isobutane

Isobutane

SCHEMBL8357971

CC(C)C.Oc1ccc2nc(S)sc2c1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.54
GAA P10253 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
DYRK1A Q13627 1/20 0.49
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA5A P35218 1/20 0.47
CA9 Q16790 1/20 0.47
CA14 Q9ULX7 1/20 0.47
CA5B Q9Y2D0 1/20 0.47
APP P05067 9/20 0.47
SULT1A1 P50225 4/20 0.47
MAPT P10636 1/20 0.47
HSD17B1 P14061 4/20 0.44
HSD17B2 P37059 3/20 0.44
AR P10275 1/20 0.43
CYP1A2 P05177 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2676185 0.93 HTT (0.61) HTTGAAL3MBTL1DYRK1ACA12
SCHEMBL8359677 0.82 HTT (0.47) HTTGAAL3MBTL1DYRK1ACA12
Chlorobenzene SCHEMBL8361496 0.81 HTT (0.49) HTTGAAL3MBTL1DYRK1ACA12
Fluorobenzene SCHEMBL8361483 0.81 APP (0.56) HTTGAAL3MBTL1DYRK1ACA12
Ethylbenzene SCHEMBL8358098 0.81 MAOB (0.50) HTTGAAL3MBTL1DYRK1AAPP
SCHEMBL3046846 0.78 CA2 (0.53) HTTGAAL3MBTL1DYRK1ACA12
Benzonitrile SCHEMBL8361486 0.77 MAOB (0.46) HTTGAAL3MBTL1DYRK1ACA12
SCHEMBL9305939 0.77 RAB9A (0.65) HTTGAAL3MBTL1APPMAPT
SCHEMBL10219916 0.77 HTT (0.56) HTTGAAL3MBTL1DYRK1ACA12
Nitrobenzene SCHEMBL8357903 0.75 MAOB (0.51) HTTGAAL3MBTL1DYRK1ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5919807-A ANTICHOLESTEROL AGENTS DR. KARL THOMAE GMBH (DE) 1999-07-06 US disclosed
EP-0824529-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-02-25 EP disclosed
WO-1996035681-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-11-14 WO disclosed