Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 3/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5357199 | 0.82 | GALR3 (0.53) | NR1H3KMT2AMEN1ACEMAPT | |
| SCHEMBL5357195 | 0.82 | GALR3 (0.53) | NR1H3KMT2AMEN1ACEMAPT | |
| SCHEMBL12942336 | 0.77 | KMT2A (0.52) | KMT2AMEN1ACEMAPTNPSR1 | |
| SCHEMBL8356127 | 0.73 | GALR3 (0.46) | NR1H3GALR3HTR4ESR1ESR2 | |
| SCHEMBL8410768 | 0.72 | KMT2A (0.50) | NR1H3KMT2AMEN1ACEMAPT | |
| SCHEMBL8226920 | 0.72 | KMT2A (0.52) | KMT2AMEN1ACEMAPTNPSR1 | |
| SCHEMBL8356489 | 0.71 | GALR3 (0.52) | NR1H3GALR3HTR4 | |
| SCHEMBL8360397 | 0.70 | GALR3 (0.50) | NR1H3KMT2AMEN1ACEMAPT | |
| SCHEMBL8406002 | 0.70 | KMT2A (0.53) | NR1H3KMT2AMEN1ACEMAPT | |
| SCHEMBL8404173 | 0.70 | KMT2A (0.50) | KMT2AMEN1ACEMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014854-A1 | 3-IMINO-2-INDOLONES FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |