Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.60 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359168 | 0.90 | NAMPT (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2152559 | 0.86 | ALDH1A1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359141 | 0.82 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359136 | 0.78 | APP (0.59) | MEN1KMT2ACYP2D6 | |
| SCHEMBL12463056 | 0.77 | MCL1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359140 | 0.77 | MEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12462828 | 0.75 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359145 | 0.75 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2152553 | 0.74 | MCL1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8354520 | 0.73 | MEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492765-B1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORP (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2003014075-A2 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |