Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463056 | 0.86 | MCL1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359154 | 0.82 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2152553 | 0.80 | MCL1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8354700 | 0.79 | MCL1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359144 | 0.76 | HTR6 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359168 | 0.75 | NAMPT (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359140 | 0.74 | MEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8354520 | 0.73 | MEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2152559 | 0.73 | ALDH1A1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8359136 | 0.72 | APP (0.59) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003014075-A2 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |