Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359154 | 0.78 | PSEN1 (0.60) | MEN1KMT2ACYP2D6 | |
| SCHEMBL12463056 | 0.78 | MCL1 (0.47) | MEN1KMT2ACYP2D6 | |
| SCHEMBL8359168 | 0.78 | NAMPT (0.55) | ALDH1A1 | |
| SCHEMBL8359127 | 0.76 | APP (0.85) | APP | |
| SCHEMBL2152559 | 0.76 | ALDH1A1 (0.52) | HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8359140 | 0.75 | MEN1 (0.51) | APPMEN1KMT2A | |
| SCHEMBL8359144 | 0.74 | HTR6 (0.55) | MEN1KMT2AHTR6 | |
| SCHEMBL8359141 | 0.72 | PSEN1 (0.61) | MEN1KMT2AALDH1A1 | |
| SCHEMBL8445146 | 0.71 | APP (0.71) | APPHTTSIGMAR1ACHECCR4 | |
| SCHEMBL2152553 | 0.71 | MCL1 (0.45) | HTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492765-B1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORP (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2003014075-A2 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |