Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.71 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359249 | 0.94 | PARP1 (0.66) | PARP1BAZ2BALDH1A1GAAMEN1 | |
| SCHEMBL14444052 | 0.89 | PARP1 (0.76) | PARP1BAZ2BALDH1A1GAAMEN1 | |
| SCHEMBL8359419 | 0.86 | PARP1 (0.74) | PARP1BAZ2BALDH1A1GAAMEN1 | |
| SCHEMBL8359236 | 0.83 | PARP1 (1.00) | PARP1BAZ2BALDH1A1GAA | |
| SCHEMBL8362894 | 0.81 | PARP1 (0.70) | PARP1BAZ2BALDH1A1MEN1MAPT | |
| SCHEMBL8362887 | 0.80 | PARP1 (0.63) | PARP1BAZ2BALDH1A1GAAMEN1 | |
| SCHEMBL8359243 | 0.79 | PARP1 (0.75) | PARP1BAZ2BALDH1A1GAACYP1A2 | |
| SCHEMBL8363083 | 0.79 | PARP1 (0.62) | PARP1BAZ2BALDH1A1GAAMEN1 | |
| SCHEMBL8359238 | 0.78 | PARP1 (1.00) | PARP1BAZ2BALDH1A1GAACTSB | |
| SCHEMBL8362888 | 0.78 | PARP1 (0.66) | PARP1BAZ2BALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247641-B2 | Compounds, derivatives, compositions, preparation and uses | MGI GP, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247641-B2 | Compounds, derivatives, compositions, preparation and uses | MGI GP, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| WO-2003014121-A9 | COMPOUNDS, DERIVATIVES, COMPOSITIONS, PREPARATION AND USES | GUILFORD PHARM INC (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2003014121-A1 | COMPOUNDS, DERIVATIVES, COMPOSITIONS, PREPARATION AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 2003-02-20 | — | — | WO | disclosed |