Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516958 | 0.83 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7015942 | 0.76 | AGTR1 (0.61) | PPARGAGTR1AGTR2 | |
| SCHEMBL9270163 | 0.73 | LMNA (0.53) | PPARGLMNAMAPK1APLNR | |
| SCHEMBL19327343 | 0.71 | PPARG (0.68) | PPARGMAPK1AGTR1AGTR2 | |
| SCHEMBL10815729 | 0.67 | PPARG (0.47) | PPARGLMNAMAPK1 | |
| SCHEMBL9124529 | 0.67 | NPC1 (0.47) | LMNAMAPK1 | |
| SCHEMBL1625262 | 0.63 | PPARG (0.42) | PPARG | |
| SCHEMBL8396608 | 0.63 | PPARG (0.45) | PPARGAGTR1AGTR2 | |
| SCHEMBL8362076 | 0.62 | AGTR2 (0.40) | PPARGAGTR1AGTR2 | |
| SCHEMBL8364392 | 0.62 | AGTR2 (0.44) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5736555-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-07 | — | — | US | disclosed |