Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359595 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL8358031 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL8050339 | 0.81 | RAB9A (0.60) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL11782932 | 0.80 | RAB9A (0.63) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL8552030 | 0.76 | HTT (0.40) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL5415087 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL2954313 | 0.75 | MIF (0.65) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 | |
| SCHEMBL12109852 | 0.73 | MAPT (0.45) | ALDH1A1NPC1SMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL14507753 | 0.72 | APP (0.64) | KDM4EALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL19782939 | 0.71 | F2RL3 (0.43) | KDM4EALDH1A1NPC1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919807-A | ANTICHOLESTEROL AGENTS | DR. KARL THOMAE GMBH (DE) | 1999-07-06 | — | — | US | disclosed |
| EP-0824529-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035681-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-11-14 | — | — | WO | disclosed |