Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.90 |
| ▸ | THRB | P10828 | 1/20 | 0.90 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | ADH1B | P00325 | 1/20 | 0.44 |
| ▸ | ADH1C | P00326 | 1/20 | 0.44 |
| ▸ | ADH1A | P07327 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208455 | 0.95 | — | — | |
| Bromide SCHEMBL23360794 | 0.92 | IDO1 (0.94) | IDO1THRBMEN1KMT2AALOX12 | |
| Ammonia Solution, Strong SCHEMBL4940619 | 0.92 | IDO1 (0.94) | IDO1THRBMEN1KMT2AALOX12 | |
| Hydrochloric Acid SCHEMBL359448 | 0.92 | IDO1 (0.94) | IDO1THRBMEN1KMT2AALOX12 | |
| Hydrochloric Acid SCHEMBL27851954 | 0.90 | IDO1 (0.90) | IDO1THRBMEN1KMT2AALOX12 | |
| Hydroxyamine SCHEMBL250901 | 0.90 | IDO1 (0.90) | IDO1THRBMEN1KMT2AALOX12 | |
| Formaldehyde SCHEMBL4447100 | 0.87 | IDO1 (0.85) | IDO1THRBMEN1KMT2AALOX12 | |
| SCHEMBL28863273 | 0.87 | IDO1 (0.85) | IDO1THRBMEN1KMT2AALOX12 | |
| Propane SCHEMBL5804162 | 0.85 | IDO1 (0.81) | IDO1THRBMEN1KMT2AALOX12 | |
| Pyrimidine SCHEMBL28996485 | 0.84 | IDO1 (0.71) | IDO1THRBMEN1KMT2AALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004955-A | ANTICOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-12-21 | — | — | US | disclosed |