Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287490 | 0.88 | CDK4 (0.38) | CDK4CCND1CCND2CCND3GSK3B | |
| SCHEMBL8287485 | 0.85 | HTR2C (0.39) | MAT2AMAPK1ALDH1A1 | |
| SCHEMBL8285279 | 0.85 | MAT2A (0.34) | CDK4CCND1CCND2CCND3MAT2A | |
| SCHEMBL8287576 | 0.84 | GSK3B (0.39) | CDK4CCND1CCND2CCND3MAT2A | |
| SCHEMBL8285261 | 0.83 | GSK3B (0.38) | CDK4CCND1CCND2CCND3MAT2A | |
| SCHEMBL8285329 | 0.83 | GSK3B (0.40) | CDK4CCND1CCND2CCND3MAT2A | |
| SCHEMBL8287459 | 0.82 | GABRP (0.38) | CDK4CCND1CCND2CCND3MAT2A | |
| SCHEMBL8287482 | 0.82 | GSK3B (0.40) | CDK4CCND1CCND2CCND3GSK3B | |
| SCHEMBL8287240 | 0.81 | HTT (0.41) | CDK4CCND1CCND2CCND3MAT2A | |
| SCHEMBL8285316 | 0.80 | PDE11A (0.40) | CDK4CCND1CCND2CCND3MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |