Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360877 | 0.92 | JAK2 (0.52) | JAK2JAK1USP30STSHSD11B1 | |
| SCHEMBL8360879 | 0.91 | JAK2 (0.51) | JAK2JAK1USP30STSHSD11B1 | |
| SCHEMBL8360881 | 0.91 | KMT2A (0.52) | JAK2JAK1USP30STSHSD11B1 | |
| SCHEMBL8363941 | 0.91 | JAK2 (0.51) | JAK2JAK1USP30STSHSD11B1 | |
| SCHEMBL8360876 | 0.90 | KCNA5 (0.55) | JAK2JAK1USP30STSPRMT5 | |
| SCHEMBL8363842 | 0.85 | CNR1 (0.54) | STSMMP1MMP9MMP13TAS2R14 | |
| SCHEMBL8363934 | 0.82 | MMP1 (0.48) | USP30STSMMP1MMP9MMP13 | |
| SCHEMBL8363938 | 0.81 | CNR1 (0.46) | MMP1MMP9MMP13MEN1KMT2A | |
| SCHEMBL24424432 | 0.81 | JAK2 (0.61) | JAK2JAK1USP30STSHSD11B1 | |
| SCHEMBL31737363 | 0.81 | JAK2 (0.61) | JAK2JAK1USP30STSHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |