Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360875 | 0.92 | JAK2 (0.51) | JAK2JAK1USP30MEN1KMT2A | |
| SCHEMBL8360879 | 0.92 | JAK2 (0.51) | JAK2JAK1ALDH1A1USP30MEN1 | |
| SCHEMBL8363941 | 0.92 | JAK2 (0.51) | JAK2JAK1USP30MEN1KMT2A | |
| SCHEMBL8360881 | 0.92 | KMT2A (0.52) | JAK2JAK1ALDH1A1ALOX15USP30 | |
| SCHEMBL8360876 | 0.91 | KCNA5 (0.55) | JAK2JAK1ALDH1A1L3MBTL1CNR1 | |
| SCHEMBL2960832 | 0.89 | STS (0.52) | JAK2JAK1ALDH1A1NPSR1TP53 | |
| SCHEMBL8363938 | 0.89 | CNR1 (0.46) | ALDH1A1NPSR1TP53ALOX15MAPK1 | |
| SCHEMBL8363842 | 0.86 | CNR1 (0.54) | ALDH1A1L3MBTL1CNR1CNR2MEN1 | |
| SCHEMBL8363934 | 0.83 | MMP1 (0.48) | ALDH1A1CNR1CNR2USP30MEN1 | |
| SCHEMBL24424432 | 0.82 | JAK2 (0.61) | JAK2JAK1USP30KMT2ASTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |