Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 4/20 | 0.52 |
| ▸ | MMP9 | P14780 | 4/20 | 0.52 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | BMP1 | P13497 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363842 | 0.95 | CNR1 (0.54) | KCNA5MMP1MMP9MMP13CNR1 | |
| SCHEMBL8363934 | 0.92 | MMP1 (0.48) | KCNA5MMP1MMP9MMP13CNR1 | |
| SCHEMBL8363942 | 0.91 | MMP1 (0.50) | KCNA5MMP1MMP9MMP13CNR1 | |
| SCHEMBL8360877 | 0.91 | JAK2 (0.52) | KCNA5MMP1MMP9MMP13JAK2 | |
| SCHEMBL8360843 | 0.90 | CNR1 (0.49) | KCNA5MMP1MMP9MMP13CNR1 | |
| SCHEMBL8363941 | 0.90 | JAK2 (0.51) | KCNA5MMP1MMP9MMP13JAK2 | |
| SCHEMBL8360879 | 0.90 | JAK2 (0.51) | JAK2JAK1STSMEN1LMNA | |
| SCHEMBL8360875 | 0.90 | JAK2 (0.51) | KCNA5MMP1MMP9MMP13JAK2 | |
| SCHEMBL8360881 | 0.90 | KMT2A (0.52) | MMP13JAK2JAK1STSMEN1 | |
| SCHEMBL8363836 | 0.90 | MMP13 (0.49) | KCNA5MMP1MMP9MMP13CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |