SCHEMBL8362802

SCHEMBL8362802

CCn1cc(-c2nc3ccc(C(=O)O)cc3n(C3CCNCC3)c2=O)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.43
CYP3A4 P08684 4/20 0.43
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
USP2 O75604 3/20 0.43
CASP1 P29466 3/20 0.43
CASP7 P55210 3/20 0.43
ALDH1A1 P00352 2/20 0.43
CYP2C19 P33261 2/20 0.43
LMNA P02545 1/20 0.43
TP53 P04637 1/20 0.43
CYP2C9 P11712 1/20 0.43
MAPK1 P28482 1/20 0.43
HIF1A Q16665 1/20 0.43
CA12 O43570 3/20 0.43
CA1 P00915 3/20 0.43
CA9 Q16790 3/20 0.43
CA2 P00918 2/20 0.41
ACSS2 Q9NR19 4/20 0.41
CLK4 Q9HAZ1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL8516014 0.88 CA12 (0.42) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8365282 0.86 CYP1A2 (0.44) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8367881 0.84 CYP1A2 (0.41) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8516675 0.81 KMT2A (0.38) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8516143 0.80 PAX8 (0.44) LMNACA12CA1CA9CA2
Trifluoroacetic Acid SCHEMBL8516996 0.78 ALDH1A1 (0.42) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8516085 0.78 KMT2A (0.40) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8516160 0.76 PAX8 (0.47) CYP1A2CYP3A4MEN1KMT2AUSP2
Trifluoroacetic Acid SCHEMBL8516758 0.76 PTGDR2 (0.39) CYP1A2CYP3A4MEN1KMT2AUSP2
SCHEMBL8365741 0.75 CA12 (0.43) CYP1A2CYP3A4MEN1KMT2AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO claimed