Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL562931 | 0.87 | APEX1 (0.38) | APEX1BLMPOLBTP53HTT | |
| SCHEMBL562480 | 0.87 | APEX1 (0.38) | APEX1BLMPOLBTP53HTT | |
| SCHEMBL10033422 | 0.79 | APEX1 (0.37) | APEX1BLMPOLBTP53BRD4 | |
| SCHEMBL2034405 | 0.79 | BRD4 (0.35) | APEX1BLMPOLBBRD4TSHR | |
| SCHEMBL563088 | 0.78 | GSK3A (0.41) | APEX1BLMBRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL3178292 | 0.76 | APEX1 (0.70) | APEX1BLMACEPOLBTP53 | |
| SCHEMBL7744060 | 0.76 | PER2 (0.37) | APEX1BLMPOLBBRD4ALDH1A1 | |
| SCHEMBL19119195 | 0.76 | APEX1 (0.70) | APEX1BLMACEPOLBTP53 | |
| SCHEMBL2034969 | 0.76 | PER2 (0.37) | APEX1BLMPOLBBRD4ALDH1A1 | |
| SCHEMBL3178301 | 0.76 | APEX1 (0.70) | APEX1BLMACEPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035368-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | ABRECHT STEFAN (CH) | 2012-02-09 | — | — | US | disclosed |
| WO-2009080500-A1 | PROCESS FOR THE PREPARATION OF PYRIDO [2,1-A] ISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| US-20090163718-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163718-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | APEX1 1510/4885BLM 917/4885ACE 41/4885 |
| US-20120035368-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | APEX1 1510/4885BLM 917/4885ACE 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.