Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.40 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL563087 | 1.00 | GSK3A (0.41) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL6949518 | 0.85 | GSK3A (0.41) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL3263412 | 0.82 | ALDH1A1 (0.40) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL3263411 | 0.82 | ALDH1A1 (0.40) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL9203370 | 0.80 | APEX1 (0.58) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL9301450 | 0.80 | APEX1 (0.58) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL9203374 | 0.80 | APEX1 (0.58) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 | |
| SCHEMBL8364228 | 0.78 | APEX1 (0.42) | ALDH1A1SMN1; SMN2KMT2ABRD4APEX1 | |
| SCHEMBL8365831 | 0.78 | FAAH (0.39) | ALDH1A1SMN1; SMN2KMT2AMEN1BRD4 | |
| SCHEMBL9301677 | 0.78 | GSK3A (0.41) | GSK3AGSK3BALDH1A1FKBP1AFKBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420818-B2 | Process for the preparation of pyrido[2,1-a] isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2234997-B1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-A]ISOQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-09-05 | — | — | EP | disclosed |
| US-20120035368-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | ABRECHT STEFAN (CH) | 2012-02-09 | — | — | US | disclosed |
| US-20090163718-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163718-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | GSK3A 1634/4885GSK3B 1485/4885ALDH1A1 62/4885 |
| US-20120035368-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | GSK3A 1634/4885GSK3B 1485/4885ALDH1A1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.