Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363473 | 0.86 | LMNA (0.35) | HSD17B10DHODHMAPK1NOTUMLMNA | |
| SCHEMBL8359915 | 0.83 | DHODH (0.34) | HSD17B10DHODHMAPK1NOTUMLMNA | |
| SCHEMBL8359337 | 0.81 | PTPN11 (0.37) | DHODHLMNA | |
| SCHEMBL8364419 | 0.78 | DYRK1A (0.34) | HSD17B10 | |
| SCHEMBL8361952 | 0.77 | TSHR (0.38) | HSD17B10LMNAMAPTPOLB | |
| SCHEMBL8357460 | 0.75 | TSHR (0.38) | HSD17B10LMNAKDM4EPOLB | |
| SCHEMBL8364433 | 0.73 | AGTR2 (0.34) | — | |
| SCHEMBL7017227 | 0.71 | — | — | |
| SCHEMBL8587862 | 0.71 | ALOX15 (0.37) | HSD17B10DHODHMAPK1 | |
| SCHEMBL8422155 | 0.71 | DHODH (0.38) | HSD17B10DHODHMAPK1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5736555-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-07 | — | — | US | disclosed |