Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.59 |
| ▸ | MMP13 | P45452 | 10/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP16 | P51512 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12150842 | 0.76 | MMP2 (0.69) | MMP2MMP13HDAC3HDAC1HDAC2 | |
| SCHEMBL5898957 | 0.74 | MMP2 (1.00) | MMP2MMP13USP2ALDH1A1 | |
| SCHEMBL5898933 | 0.74 | MMP2 (1.00) | MMP2MMP13HDAC6MMP3 | |
| SCHEMBL7076468 | 0.73 | KMT2A (0.59) | MMP2MMP13TSHRHDAC6ALDH1A1 | |
| SCHEMBL5899024 | 0.72 | MMP2 (1.00) | MMP2MMP13TSHRALDH1A1 | |
| SCHEMBL7073728 | 0.72 | MMP2 (0.60) | MMP2MMP13TSHRACLYHDAC3 | |
| SCHEMBL7076239 | 0.72 | MMP2 (0.60) | MMP2MMP13ACLYHDAC3HDAC1 | |
| SCHEMBL8364765 | 0.72 | MMP2 (0.69) | MMP2MMP13MMP9MMP8MMP12 | |
| SCHEMBL7079810 | 0.72 | ALDH1A1 (0.59) | MMP2MMP13TSHRUSP2HDAC3 | |
| SCHEMBL5898966 | 0.69 | CHRM1 (0.60) | MMP2MMP13ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007954-A2 | SULFONYL ARYL HYDROXAMATES AND THEIR USE AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-01-30 | — | — | WO | disclosed |