Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666272 | 0.84 | TRPV3 (0.51) | KIF11LMNATRPV3 | |
| SCHEMBL2666244 | 0.80 | MEN1 (0.59) | NPC1RAB9AMAPTLMNAHTT | |
| SCHEMBL30885597 | 0.79 | NPC1 (0.60) | NPC1RAB9AKIF11MAPTNPSR1 | |
| SCHEMBL7032910 | 0.79 | MEN1 (0.44) | NPC1RAB9AMAPTHPGDALDH1A1 | |
| SCHEMBL16455975 | 0.78 | KIT (0.41) | LMNAHTTXDHALDH1A1KDM4E | |
| SCHEMBL10120033 | 0.78 | KIF11 (0.56) | NPC1RAB9AKIF11MAPTNPSR1 | |
| SCHEMBL28330524 | 0.77 | ESR1 (0.40) | NPC1MAPTHPGDTP53ALDH1A1 | |
| SCHEMBL16455969 | 0.77 | DGAT1 (0.45) | NPC1RAB9A | |
| SCHEMBL2666289 | 0.77 | MEN1 (0.56) | NPC1RAB9AMAPTLMNAL3MBTL1 | |
| SCHEMBL6325641 | 0.77 | MEN1 (0.45) | NPC1RAB9AMAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076983-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-03 | — | — | WO | disclosed |