Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8369457 | 0.88 | KDM4E (0.59) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL8366356 | 0.82 | CYP2D6 (0.63) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL9766147 | 0.81 | ALDH1A1 (0.60) | KDM4EALDH1A1GAAPOLBHSD17B10 | |
| SCHEMBL674415 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1POLBTDP1HSD17B10 | |
| Hydrochloric Acid SCHEMBL9293745 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL8364405 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL28982738 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL3021147 | 0.78 | AKR1C2 (0.61) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL31324167 | 0.77 | KDM4E (0.73) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL28687268 | 0.77 | KDM4E (0.73) | KDM4EALDH1A1L3MBTL1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |
| EP-0850235-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997010238-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1997-03-20 | — | — | WO | disclosed |