Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364405 | 0.86 | KDM4E (0.55) | CYP2D6KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL8366255 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL9152213 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL8369457 | 0.81 | KDM4E (0.59) | CYP2D6KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL29375720 | 0.78 | CYP2D6 (1.00) | CYP2D6KDM4EALDH1A1L3MBTL1TDP1 | |
| SCHEMBL676574 | 0.78 | CYP2D6 (1.00) | CYP2D6KDM4EALDH1A1L3MBTL1TDP1 | |
| SCHEMBL2267796 | 0.77 | ALDH1A1 (0.66) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL9160413 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL2798566 | 0.77 | KDM4E (0.75) | KDM4EALDH1A1L3MBTL1GAAPOLB | |
| Hydrochloric Acid SCHEMBL9293745 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1L3MBTL1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |
| EP-0850235-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997010238-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1997-03-20 | — | — | WO | disclosed |