Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.48 |
| ▸ | EDNRA | P25101 | 8/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711797 | 0.80 | CA2 (0.58) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16610066 | 0.77 | TYMS (0.53) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL12603022 | 0.76 | CA2 (0.65) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6750357 | 0.76 | F2 (0.59) | F2HTTTDP1L3MBTL1KMT2A | |
| SCHEMBL8366342 | 0.75 | F2 (0.42) | CA2F2PRSS2EDNRACYP1A2 | |
| SCHEMBL714171 | 0.75 | CA2 (0.52) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18487536 | 0.75 | KDM4E (0.48) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7440192 | 0.73 | F2 (0.55) | F2PRSS2KMT2AKDM4EHSD17B10 | |
| SCHEMBL714494 | 0.72 | TYMS (0.57) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18487742 | 0.72 | DYRK1A (0.41) | CA2F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883405-A4 | AMIDINO PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0883405-A1 | AMIDINO PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997024135-A1 | AMIDINO PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-07-10 | — | — | WO | disclosed |