Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.47 |
| ▸ | NQO2 | P16083 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366206 | 0.88 | KDM4E (0.55) | ALDH1A1KDM4EHPGDAKR1C3AKR1C2 | |
| SCHEMBL8366324 | 0.84 | THRB (0.47) | ALDH1A1KDM4EHPGDPOLBMAPT | |
| SCHEMBL8367855 | 0.84 | HPGD (0.43) | ALDH1A1KDM4EHPGDAKR1C3POLB | |
| SCHEMBL9152250 | 0.82 | MAPT (0.59) | ALDH1A1KDM4EHPGDNQO2POLB | |
| SCHEMBL2686296 | 0.81 | MTNR1A (0.65) | AKR1C3MTNR1AMTNR1BNQO2AKR1C2 | |
| SCHEMBL8367875 | 0.81 | BRD4 (0.45) | ALDH1A1KDM4EHPGDAKR1C3AKR1C2 | |
| SCHEMBL8648192 | 0.77 | AKR1C3 (0.68) | ALDH1A1AKR1C3MTNR1AMTNR1BNQO2 | |
| SCHEMBL6208739 | 0.76 | MAPT (0.56) | ALDH1A1KDM4EHPGDMTNR1AMTNR1B | |
| SCHEMBL8369457 | 0.75 | KDM4E (0.59) | ALDH1A1KDM4EHPGDAKR1C3MTNR1A | |
| SCHEMBL29187763 | 0.74 | AKR1C3 (0.47) | ALDH1A1KDM4EHPGDAKR1C3MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |