Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.65 |
| ▸ | NQO2 | P16083 | 1/20 | 0.65 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685182 | 0.87 | MTNR1A (0.63) | MTNR1AMTNR1BNQO2AKR1C3ADRB2 | |
| SCHEMBL15242222 | 0.86 | MTNR1A (0.70) | MTNR1AMTNR1BNQO2ADRB2HTR6 | |
| SCHEMBL2686872 | 0.84 | SPR (0.62) | MTNR1AMTNR1BNQO2AKR1C3 | |
| SCHEMBL20604920 | 0.83 | KDM4E (0.47) | MTNR1AMTNR1BNQO2AKR1C3ADRB2 | |
| SCHEMBL8529581 | 0.82 | CPT1A (0.49) | MTNR1AMTNR1BNQO2AKR1C3 | |
| SCHEMBL13888101 | 0.82 | ADRB2 (0.70) | MTNR1AMTNR1BNQO2AKR1C3ADRB2 | |
| SCHEMBL24723814 | 0.82 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2AKR1C3ADRB2 | |
| SCHEMBL8366372 | 0.81 | ALDH1A1 (0.56) | MTNR1AMTNR1BNQO2AKR1C3AKR1C2 | |
| SCHEMBL24723269 | 0.81 | MTNR1A (0.56) | MTNR1AMTNR1BNQO2AKR1C3ADRB2 | |
| SCHEMBL16494963 | 0.80 | HTR6 (0.57) | MTNR1AMTNR1BNQO2AKR1C3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638034-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062462-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062462-A1 | SUBSTITUTED HETEROAROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-05-18 | — | — | WO | disclosed |
| US-20120115903-A1 | Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
| US-20120115903-A1 | Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
| US-20120115903-A1 | Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | GRUENENTHAL GMBH (DE) | 2012-05-10 | — | — | US | disclosed |
| US-5703070-A | PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115903-A1 | Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands | TRPV1, OPRM1, OPRK1 | MTNR1A 304/4885MTNR1B 489/4885NQO2 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.