Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 4/20 | 0.60 |
| ▸ | NMT1 | P30419 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117733 | 0.86 | CYP1A2 (0.65) | NMT2NMT1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7762381 | 0.84 | NMT2 (0.57) | NMT2NMT1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL2833179 | 0.76 | PKM (0.50) | NMT2NMT1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL8366867 | 0.74 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2HSD17B10HPGD | |
| SCHEMBL23009237 | 0.73 | KDM4E (0.59) | KDM4EALDH1A1CYP1A2HSD17B10HPGD | |
| SCHEMBL29538580 | 0.73 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL12501235 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL7388068 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL2551862 | 0.72 | HASPIN (0.62) | NMT2NMT1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL14400286 | 0.72 | KDM4E (0.48) | NMT2NMT1KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786139-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2010-08-31 | — | — | US | disclosed |
| US-20080300240-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300240-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | NMT2 3510/4885NMT1 2862/4885KDM4E 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.