SCHEMBL836728

SCHEMBL836728

O=C(O)[C@H](Cc1ccc(Oc2ccc(O)cc2)cc1)N(I)I

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.46
PCNA P12004 2/20 0.46
PPARG P37231 7/20 0.43
PPARA Q07869 7/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
LTA4H P09960 1/20 0.42
NR1H2 P55055 1/20 0.42
BAX Q07812 1/20 0.42
LDHA P00338 1/20 0.41
PPARD Q03181 2/20 0.41
FFAR1 O14842 1/20 0.41
PARP10 Q53GL7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10938101 1.00 SLC7A5 (0.46) SLC7A5PCNAPPARGPPARAMEN1
SCHEMBL169322 0.91 SLC7A5 (0.55) SLC7A5ESR1ESR2
SCHEMBL169321 0.91 SLC7A5 (0.55) SLC7A5ESR1ESR2
Methane SCHEMBL17267562 0.89 SLC7A5 (0.53) SLC7A5ESR1ESR2
SCHEMBL11198590 0.88 SLC7A5 (0.47) SLC7A5PCNAPPARGPPARAMEN1
SCHEMBL30716564 0.88 PCNA (0.44) SLC7A5PCNAPPARGPPARAMEN1
SCHEMBL11198579 0.88 SLC7A5 (0.47) SLC7A5PCNAPPARGPPARAMEN1
SCHEMBL17845882 0.87 PCNA (0.37) SLC7A5PCNAPPARGPPARALDHA
SCHEMBL7276725 0.85 SLC7A5 (0.46) SLC7A5PCNAPPARGPPARAMEN1
SCHEMBL31409225 0.84 ESR1 (0.51) PCNAMEN1KMT2AESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 368 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260049178-A1 CROSSLINKING AGENTS AND MEDICAL HYDROGELS FORMED THEREFROM BOSTON SCIENTIFIC SCIMED, INC. (US) 2026-02-19 US claimed
EP-4684002-A2 THYROCYTES AND USES THEREOF Lifenet Health (US) 2026-01-28 EP claimed
US-20250345488-A1 CROSSLINKED HYDROGELS WITH ENHANCED RADIOPACITY FOR MEDICAL APPLICATIONS BOSTON SCIENTIFIC SCIMED, INC. (US) 2025-11-13 US claimed
CN-120121693-A Identification of thyroid hormones using reactive heterogeneous nanopores 南京大学 2025-06-10 CN claimed
WO-2024197069-A2 THYROCYTES AND USES THEREOF LIFENET HEALTH (US) 2024-09-26 WO claimed
CN-116699150-A Biosensing analysis method for detecting thyroid hormone binding activity in water sample 清华大学 2023-09-05 CN claimed
CN-114609265-A Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology 徐州医科大学 2022-06-10 CN claimed
CN-114609266-A Application of marker in preparation of diagnostic reagent for thyroid related diseases 徐州医科大学 2022-06-10 CN claimed
US-9890116-B2 Process for the preparation of a sulfated derivative of 3,5-diiodo-O-[3-iodophenyl]-L-tyrosine BRACCO IMAGING S.P.A. (IT) 2018-02-13 US claimed
EP-2694471-B1 PROCESS FOR THE PREPARATION OF A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE BRACCO IMAGING SPA (IT) 2017-08-02 EP claimed
WO-2001035902-A9 STABILIZED THYROXINE COMPOUNDS LOTUS BIOCHEMICAL CORP (US) 2001-11-29 WO claimed
WO-2001035902-A2 STABILIZED THYROXINE COMPOUNDS LOTUS BIOCHEMICAL CORPORATION (US) 2001-05-25 WO claimed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO claimed
EP-0357725-B1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF LUNG OBSTRUCTIONS SMITH, Ulf Per Gustav (SE) 1992-04-15 EP claimed
EP-0073865-B1 DERIVATIVES OF IODOTHYRONINE COMPOUNDS AND THEIR USE IN AN ASSAY FOR THE FREE IODOTHYRONINE COMPOUNDS AMERSHAM INTERNATIONAL plc (GB) 1986-01-29 EP claimed
EP-0093653-B1 PROCESS FOR THE PREPARATION OF IODO-THYRONINES AND IODO-THYROACETIC ACIDS BY ELECTROCHEMICAL REDUCTION AT A CONTROLLED POTENTIAL SPIRAL Société à responsabilité limitée dite : (FR) 1985-07-10 EP claimed
US-4490221-A Process for preparing iodothyronines and iodothyroacetic acids by electrochemical reduction at controlled potential SPIRAL SOCIETE A RESPONSABILITE LIMITEE DITE (FR) 1984-12-25 US claimed
US-4426453-A Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds AMERSHAM INTERNATIONAL LIMITED (GB) 1984-01-17 US claimed
EP-0093653-A1 Process for the preparation of iodo-thyronines and iodo-thyroacetic acids by electrochemical reduction at a controlled potential SPIRAL Société à responsabilité limitée dite : (FR) 1983-11-09 EP claimed
EP-0073865-A1 Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds AMERSHAM INTERNATIONAL plc (GB) 1983-03-16 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049178-A1 CROSSLINKING AGENTS AND MEDICAL HYDROGELS FORMED THEREFROM NPPA, MACF1, IGF1R SLC7A5 654/4885PCNA 67/4885PPARG 2055/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.