Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365378 | 0.87 | CRHR1 (0.52) | CRHR1MAPTHPGDALPLHSD11B1 | |
| SCHEMBL5738501 | 0.71 | CRHR1 (0.51) | CRHR1MAPTHPGDDPP4 | |
| SCHEMBL28070698 | 0.68 | HSD11B1 (0.47) | CRHR1MAPTHPGDALPLHSD11B1 | |
| SCHEMBL14107169 | 0.68 | CRHR1 (0.44) | CRHR1MAPTHSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL8368586 | 0.68 | MAPT (0.49) | CRHR1MAPTHPGDALPLHSD11B1 | |
| SCHEMBL12653943 | 0.68 | HSD11B1 (0.50) | CRHR1HSD11B1HSP90AA1HSP90AB1DPP4 | |
| SCHEMBL802336 | 0.66 | GUSB (0.58) | HPGDHSD11B1HSP90AA1HSP90AB1DPP4 | |
| SCHEMBL8746755 | 0.65 | MAPT (0.49) | CRHR1MAPTHPGDALPLHSD11B1 | |
| SCHEMBL785502 | 0.64 | HSD11B1 (0.46) | CRHR1HSD11B1HSP90AA1HSP90AB1DPP4 | |
| SCHEMBL10940086 | 0.64 | AKT1 (0.46) | CRHR1MAPTHPGDALPLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999045007-A1 | CRF ANTAGONISTIC PYRAZOLO[4,3-B]PYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-09-10 | — | — | WO | disclosed |