Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280084 | 0.76 | PSEN1 (0.34) | MAPTKDM4EHPGDPSEN1PSEN2 | |
| SCHEMBL8368744 | 0.73 | MAPT (0.47) | MAPTXBP1LMNASMN1; SMN2KDM4E | |
| SCHEMBL1903649 | 0.69 | HDAC2 (0.54) | MAPTSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL21587872 | 0.69 | HDAC2 (0.54) | MAPTSMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL12966414 | 0.68 | KMT2A (0.56) | KMT2A | |
| SCHEMBL31326505 | 0.68 | KMT2A (0.56) | KMT2A | |
| SCHEMBL38660483 | 0.68 | KMT2A (0.56) | KMT2A | |
| SCHEMBL21187795 | 0.68 | KMT2A (0.56) | KMT2A | |
| SCHEMBL29398874 | 0.68 | KMT2A (0.56) | KMT2A | |
| SCHEMBL5649671 | 0.67 | FAAH (0.35) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292573-B1 | SUBSTITUTED THIOACETAMIDES | CEPHALON INC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2186803-A2 | Substituted thioacetamides | CEPHALON, INC. (US) | 2010-05-19 | — | — | EP | disclosed |
| US-20080027228-A1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-7268132-B2 | Thio substituted with a hetero multiring group; sleepiness, promotion of wakefulness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, attention deficit hyperactivity disorder | CEPHALON, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268132-B2 | Thio substituted with a hetero multiring group; sleepiness, promotion of wakefulness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, attention deficit hyperactivity disorder | CEPHALON, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-RE39575-E1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-RE39575-E1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2003037853-A1 | SUBSTITUTED THIOACETAMIDES | CEPHALON, INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027228-A1 | Substituted thioacetamides | TST, TTR, TBCA | MAPT 1440/4885XBP1 2717/4885LMNA 3782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.