Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.44 |
| ▸ | CDC25A | P30304 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FGB | P02675 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9016831 | 0.81 | MAPT (0.56) | MAPTXBP1MAP2K7CDC25ACDC25B | |
| SCHEMBL22303956 | 0.76 | CYP2C19 (0.50) | CYP2C19MAP2K7CDC25ACDC25BCYP1A2 | |
| SCHEMBL9629366 | 0.74 | ALDH1A1 (0.40) | MAPTTSHRALDH1A1LMNAKMT2A | |
| SCHEMBL1107119 | 0.73 | ACHE (0.47) | MAPTXBP1ALDH1A1LMNAPKM | |
| SCHEMBL14280080 | 0.73 | MAPT (0.51) | MAPTXBP1CYP1A2TSHRALDH1A1 | |
| SCHEMBL8368745 | 0.73 | MAPT (0.41) | MAPTXBP1ALDH1A1LMNAPKM | |
| SCHEMBL3136529 | 0.72 | EGFR (0.54) | MAPTCYP1A2TSHRKMT2AAPEX1 | |
| SCHEMBL3471771 | 0.71 | KIF11 (0.48) | MAPTXBP1CYP2C19CYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL8993456 | 0.70 | EGFR (0.53) | MAPTCYP1A2TSHRKMT2AAPEX1 | |
| SCHEMBL8993220 | 0.70 | EGFR (0.58) | MAPTCYP1A2TSHRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292573-B1 | SUBSTITUTED THIOACETAMIDES | CEPHALON INC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2186803-A2 | Substituted thioacetamides | CEPHALON, INC. (US) | 2010-05-19 | — | — | EP | disclosed |
| US-20080027228-A1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-20080027228-A1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-7268132-B2 | Thio substituted with a hetero multiring group; sleepiness, promotion of wakefulness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, attention deficit hyperactivity disorder | CEPHALON, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268132-B2 | Thio substituted with a hetero multiring group; sleepiness, promotion of wakefulness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, attention deficit hyperactivity disorder | CEPHALON, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-RE39575-E1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-RE39575-E1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2003037853-A1 | SUBSTITUTED THIOACETAMIDES | CEPHALON, INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027228-A1 | Substituted thioacetamides | TST, TTR, TBCA | MAPT 1440/4885XBP1 2717/4885CYP2C19 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.