Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602227 | 0.81 | MEN1 (0.55) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL8371535 | 0.81 | MEN1 (0.65) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL5655893 | 0.75 | MEN1 (0.52) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL5666060 | 0.75 | MEN1 (0.55) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL8370485 | 0.73 | MEN1 (0.65) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL8517238 | 0.71 | MEN1 (0.56) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL4725263 | 0.70 | DRD2 (0.60) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL8370598 | 0.70 | OPRM1 (0.44) | ALDH1A1DRD2DRD4DRD3OPRK1 | |
| SCHEMBL7602250 | 0.69 | MEN1 (0.56) | MEN1KMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL5656348 | 0.69 | MEN1 (0.52) | MEN1KMT2ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |