Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD4 | P21917 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436302 | 0.86 | TSHR (0.66) | DRD2DRD4DRD3KMT2ATSHR | |
| SCHEMBL3436467 | 0.83 | OPRM1 (0.55) | DRD2DRD4DRD3KMT2ATSHR | |
| SCHEMBL3187550 | 0.82 | DRD2 (0.56) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL11392447 | 0.78 | MEN1 (0.67) | DRD2DRD4DRD3KMT2ATSHR | |
| SCHEMBL7597607 | 0.78 | MEN1 (0.67) | DRD2DRD4DRD3KMT2ATSHR | |
| SCHEMBL8370595 | 0.78 | MEN1 (0.62) | DRD2DRD4DRD3KMT2ATSHR | |
| SCHEMBL3200095 | 0.76 | ADRA1B (0.56) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL5010587 | 0.76 | HTT (0.56) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL18181904 | 0.76 | TSHR (0.63) | DRD2DRD4DRD3KMT2ATSHR | |
| SCHEMBL3436303 | 0.74 | HTT (0.53) | DRD2DRD4KMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021250-A2 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING BCL-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-02-21 | — | — | WO | disclosed |