Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.45 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.39 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368659 | 0.89 | MAPT (0.48) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8369531 | 0.87 | CASP3 (0.51) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8371662 | 0.86 | CDK4 (0.50) | CDK4MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8367303 | 0.80 | CDK4 (0.45) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8367302 | 0.77 | CDK4 (0.56) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8368953 | 0.77 | SMN1; SMN2 (0.59) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8370506 | 0.75 | MAPT (0.51) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8371701 | 0.75 | SMN1; SMN2 (0.45) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8656092 | 0.73 | MAPT (0.77) | CASP3SENP8SENP7SENP6CDK4 | |
| SCHEMBL8368813 | 0.73 | CDK4 (0.53) | CDK4MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999052365-A1 | ANTICANCER AGENTS | ELI LILLY AND COMPANY (US) | 1999-10-21 | — | — | WO | disclosed |