Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.59 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.59 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.59 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8369531 | 0.90 | CASP3 (0.51) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8370506 | 0.90 | MAPT (0.51) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8371701 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8368813 | 0.87 | CDK4 (0.53) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8367237 | 0.81 | MAPT (0.55) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8367064 | 0.79 | CDK4 (0.62) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8541266 | 0.78 | AGTR1 (0.43) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8368653 | 0.78 | MAPT (0.70) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8368659 | 0.77 | MAPT (0.48) | SMN1; SMN2KMT2AMAPTMEN1TDP1 | |
| SCHEMBL8370509 | 0.77 | CASP3 (0.48) | SMN1; SMN2KMT2AMAPTMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999052365-A1 | ANTICANCER AGENTS | ELI LILLY AND COMPANY (US) | 1999-10-21 | — | — | WO | disclosed |