Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.70 |
| ▸ | GSK3A | P49840 | 3/20 | 0.70 |
| ▸ | GSK3B | P49841 | 3/20 | 0.70 |
| ▸ | PRKX | P51817 | 3/20 | 0.70 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.70 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.70 |
| ▸ | CDC7 | O00311 | 2/20 | 0.70 |
| ▸ | PLK4 | O00444 | 2/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.70 |
| ▸ | PIM1 | P11309 | 2/20 | 0.70 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.70 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.70 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.70 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.70 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345066 | 1.00 | PLK1 (0.70) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL4376047 | 0.82 | PLK1 (1.00) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL4376049 | 0.82 | PLK1 (1.00) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL7349452 | 0.80 | PLK1 (0.55) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL19956891 | 0.77 | KMT2A (0.49) | PLK1ROCK1ROCK2CHEK2GSK3A | |
| SCHEMBL6983541 | 0.77 | MAPKAPK2 (0.52) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL6989283 | 0.76 | ABCC9 (0.51) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL7555212 | 0.76 | ABCC9 (0.51) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL6987237 | 0.76 | KMT2A (0.42) | PLK1ROCK1CHEK1ROCK2CHEK2 | |
| SCHEMBL8669622 | 0.75 | PLK1 (0.61) | PLK1ROCK1CHEK1ROCK2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796243-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PROD (US) | 1999-01-27 | — | — | EP | disclosed |
| EP-0796243-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996015103-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |
| US-5512585-A | MUSCLE RELAXANT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-30 | — | — | US | disclosed |