Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 5/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PRKX | P51817 | 2/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.40 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349452 | 0.81 | PLK1 (0.55) | KMT2ARAD52MAPKAPK2TBXA2RTBXAS1 | |
| SCHEMBL19956891 | 0.79 | KMT2A (0.49) | KMT2ARAD52MAPKAPK2PLK1ROCK1 | |
| SCHEMBL7345066 | 0.76 | PLK1 (0.70) | MAPKAPK2PLK1ROCK1CHEK1ROCK2 | |
| SCHEMBL8371986 | 0.76 | PLK1 (0.70) | MAPKAPK2PLK1ROCK1CHEK1ROCK2 | |
| SCHEMBL7350556 | 0.72 | MAPKAPK2 (0.43) | KMT2ARAD52MAPKAPK2ROCK1CHEK1 | |
| SCHEMBL7346763 | 0.72 | TDO2 (0.50) | KMT2ARAD52NPC1RAB9ATDP2 | |
| SCHEMBL2771874 | 0.72 | POLB (0.46) | KMT2ARAD52RAB9ATDP2NSD2 | |
| SCHEMBL7351783 | 0.72 | RAD52 (0.45) | KMT2ARAD52NPC1RAB9ATDP2 | |
| SCHEMBL7555212 | 0.70 | ABCC9 (0.51) | KMT2AMAPKAPK2PLK1ROCK1CHEK1 | |
| SCHEMBL4023982 | 0.69 | POLB (0.55) | KMT2ARAD52NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |