Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8374493 | 1.00 | MEN1 (0.46) | MEN1POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8374897 | 0.87 | TBXAS1 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8438436 | 0.87 | TBXAS1 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| Guanidine SCHEMBL8518148 | 0.82 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10988022 | 0.81 | MAPT (0.49) | MEN1POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL10988025 | 0.81 | MAPT (0.49) | MEN1POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8374500 | 0.75 | MAPT (0.46) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL8374503 | 0.75 | MAPT (0.46) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL2420053 | 0.74 | MAPT (0.53) | MEN1POLBKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2420056 | 0.74 | MAPT (0.53) | MEN1POLBKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755919-B1 | Substituted cinnamic acid guanidides, process for their preparation, their use as cardiovascualr medicament or diagnostic agent, as well as medicament containing them | HOECHST AG (DE) | 1999-11-17 | — | — | EP | disclosed |
| US-5883133-A | CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-16 | — | — | US | disclosed |
| EP-0755919-A2 | Substituted cinnamic acid guanidides, process for their preparation, their use as cardiovascualr medicament or diagnostic agent, as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-01-29 | — | — | EP | disclosed |